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Target intelligence / Profile preview
Olfactory receptor family 10 subfamily J member 4 (OR10J4)
- Target
- OR10J4
- Molecular classification
- G protein-coupled receptor (GPCR), Olfactory receptor, Pseudogene
01
Overview
The olfactory receptor family 10 subfamily J member 4 (OR10J4) is part of the large family of olfactory GPCRs that typically detect odorant molecules, initiating neural signaling for the perception of smell. In humans, OR10J4 is classified as a pseudogene, implying that it does not encode a functional receptor protein and does not participate in canonical olfactory signaling or serve as a therapeutic target. Olfactory receptors generally share a seven-transmembrane domain structure characteristic of class A GPCRs and, when functional, mediate G protein-dependent signal transduction upon ligand (odorant) binding. The gene for OR10J4 (HGNC:15408; NCBI Gene:391121; Ensembl:ENSG00000249730) lacks evidence of functional protein expression in human tissues.
- Other names
- OR10J4OR10J4POST717olfactory receptor 10J4olfactory receptor, family 10, subfamily J, member 4 pseudogene
02
Mechanism of action
None described. Olfactory receptors typically act via GPCR-mediated signal transduction, but OR10J4 does not function in this role in humans.
03
Biological functions
In species where functional, olfactory receptors mediate recognition and transduction of odorant molecules. For human OR10J4, no confirmed biological activity has been reported due to its pseudogene status.
04
Disease associations
None reported for OR10J4. Olfactory receptor family members generally have not been directly implicated in specific diseases through this pseudogene.
05
Safety considerations
None specific. There are no reported safety concerns or therapeutic challenges related to OR10J4.
06
Interacting drugs
None. There are no known drugs targeting OR10J4, consistent with its pseudogene designation and lack of functional protein product.
07
Biomarkers
None known. OR10J4 is not used as a biomarker for patient selection or efficacy monitoring.
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