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Olfactory receptor family 10 subfamily J member 5 (OR10J5)
- Target
- OR10J5
- Molecular classification
- G protein-coupled receptor, Olfactory receptor, Seven-transmembrane receptor
01
Overview
OR10J5 (olfactory receptor family 10 subfamily J member 5) is a G protein-coupled receptor (GPCR) primarily expressed in the olfactory epithelium, where it detects odorant molecules such as lyral and α-cedrene to mediate the sense of smell. In addition to its traditional olfactory role, OR10J5 is expressed in non-olfactory tissues (e.g., endothelial cells, hepatocytes). It participates in processes such as angiogenesis (via AKT pathway activation), regulation of cell migration, and control of lipid metabolism via cAMP-PKA signaling in hepatocytes. While of research interest for these non-canonical roles, it is not currently a therapeutic drug target and has no established disease associations.
- Other names
- Olfactory receptor family 10 subfamily J member 5OR10J5O10J5Olfactory receptor 10J5
02
Mechanism of action
Agonism (by odorants such as lyral or α-cedrene, leading to activation of GPCR signaling in expressing cells)
03
Biological functions
Signal transduction (via GPCR mechanisms)Odorant recognition and smell perceptionAngiogenesis regulation in endothelial cells (in response to lyral)Regulation of cell migration and adhesion in some non-olfactory tissues (via AKT pathway)Regulation of lipid accumulation in hepatocytes (via cAMP-PKA pathway)Possible role in sperm chemotaxis and motility
04
Disease associations
Other
05
Safety considerations
None
06
Interacting drugs
None
07
Biomarkers
None
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