Olfactory receptor family 10 subfamily K member 1 (OR10K1)

Olfactory receptor family 10 subfamily K member 1 (OR10K1) is a **human G protein-coupled receptor (GPCR)** encoded by the *OR10K1* gene, part of the largest gene family in the human genome[9][7]. Like other olfactory receptors, it possesses a canonical 7-transmembrane domain structure and functions by recognizing odorant molecules in the nasal epithelium, thereby initiating neuronal signals involved in the sense of smell[9][3][7]. Olfactory receptors function via G-protein signaling that ultimately depolarizes sensory neurons upon odorant binding[3]. The specific ligand spectrum and physiological role of OR10K1 are not characterized; it is one of hundreds of similar, highly variable receptors expressed mainly in the olfactory epithelium[9][7][4]. Although some olfactory receptors are expressed in non-olfactory tissues with emerging roles in physiology and disease, there is currently no evidence that OR10K1 has significant non-olfactory functions[5]. No drugs or disease associations are known for this receptor at present.

Other names

Olfactory receptor 10K1Olfactory receptor OR1-6OR1-6olfactory receptor 10K1olfactory receptor OR1-6OR10K1

Not applicable / unknown (For olfactory receptors in general: odorant binding activates the GPCR, which signals via G-proteins leading to cAMP-mediated depolarization of neurons) No relevant data for drug-based mechanism