Olfactory receptor family 11 subfamily H member 4 (OR11H4)

Olfactory receptor family 11 subfamily H member 4 (OR11H4) is a human olfactory receptor encoded by the OR11H4 gene. This protein belongs to the large G protein-coupled receptor (GPCR) superfamily characterized by seven transmembrane domains. Olfactory receptors like OR11H4 are primarily expressed in the sensory neurons of the olfactory epithelium, where they recognize and bind odorant molecules, initiating neuronal signaling and triggering the perception of smell. The olfactory receptor gene family is the largest in the human genome. OR11H4 is a functional gene (not a pseudogene) and is evolutionarily conserved with orthologs in mammals such as mice, rats, dogs, and cows. While structurally homologous to other well-studied GPCRs, the specific ligands recognized by OR11H4 and its precise odorant sensitivities are not detailed in current literature. There are no drugs targeting OR11H4, and its major characterized role is in normal olfactory function rather than disease[2][4][5][6].

Other names

OR14-36HsOR14.1.29ORL3686olfactory receptor 11H4olfactory receptor OR14-36

Not established (Olfactory receptor activation is by binding of odorant ligands leading to G protein activation and downstream neuronal signaling. No drugs with annotated MoA for this specific receptor)