Target intelligence / Profile preview

Olfactory receptor family 13 subfamily F member 1 (OR13F1)

Target
OR13F1
Molecular classification
G protein-coupled receptor (GPCR), Seven-transmembrane receptor, Receptor
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Overview

Olfactory receptor family 13 subfamily F member 1 (OR13F1) is a member of the large olfactory receptor superfamily, which enables humans to detect and discriminate odorants. It belongs to the G protein-coupled receptor (GPCR) family, characterized by seven transmembrane domains, and is encoded by a single coding exon gene. OR13F1 is expressed in the olfactory epithelium, where it recognizes specific odorant molecules and initiates the neuronal response leading to the perception of smell through G protein-mediated signaling. While olfactory receptors have broad but selective hydrophobic ligand recognition, their physiological function is focused on sensory transduction with no established disease links or drug interactions. The gene nomenclature is species-specific, and there is no evidence of inaccurate naming, spurious disease claims, or direct therapeutic relevance beyond research into chemosensory signaling

Other names
Olfactory receptor 13F1Olfactory receptor OR9-6OR9-6O13F1_HUMAN (protein)Olfactory receptor family 13 subfamily F member 1
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Mechanism of action

Odorant molecule binding (typically small, volatile organic compounds) triggers activation of coupled G proteins, initiating intracellular signaling cascade

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Biological functions

Signal transductionOdorant recognition (initiates neuronal response for perception of smell)G protein-mediated transduction of olfactory signals
04

Disease associations

Other (No well-established direct links to major human diseases in current literature; primarily physiological roles in olfaction)No direct evidence of involvement in cancer, inflammation, neurodegenerative, cardiovascular, or infectious diseases
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Safety considerations

None notable; as a peripheral sensory receptor, therapeutic modulation is not associated with significant safety challenges. Its role is specific to smell, and systemically targeted interventions are not clinically relevant at present
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Interacting drugs

None documented (No approved or investigational small molecules or biologics reported to interact with OR13F1; research on olfactory receptor targeting drugs is limited)
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Biomarkers

None established; not currently used as a biomarker for patient selection or efficacy monitoring

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