Olfactory receptor family 14 subfamily A member 2 (OR14A2)

Olfactory receptor family 14 subfamily A member 2 (OR14A2) is a member of the olfactory receptor family of G protein-coupled receptors (GPCRs), characterized by a 7-transmembrane domain architecture similar to that found in neurotransmitter and hormone receptors[1][5]. OR14A2 is encoded by a single coding-exon gene and functions in the detection and transduction of odorant signals; when ligand (odorant) binding occurs in the nasal epithelium, the receptor triggers a neuronal response that leads to the perception of smell[5]. This protein belongs to one of the largest gene families in the human genome and is primarily expressed in olfactory tissues. Like other olfactory receptors, OR14A2 likely plays a role strictly in sensory biology, and there is limited evidence for direct involvement in human disease or for therapeutic modulation by current or investigational drugs[4]. OR14A2 is also catalogued under alternative names such as OR5AX1 and OR5AX1P, and pseudogene annotations reflect the complex genomic organization of olfactory receptor subfamilies.

Other names

OR14A2Olfactory receptor 14A2OR5AX1OR5AX1POlfactory receptor 5AX1Olfactory receptor OR1-31Olfactory receptor, family 5, subfamily AX, member 1 pseudogene

Activation by odorant binding triggers conformational change, leading to G protein activation and neuronal signaling [1][4]