Target intelligence / Profile preview

Olfactory receptor family 14 subfamily K member 1 (OR14K1)

Target
OR14K1
Molecular classification
G protein-coupled receptor, Receptor, Transmembrane protein
01

Overview

Olfactory receptor family 14 subfamily K member 1 is a member of the olfactory receptor gene family, which is the largest in the human genome[1][3]. These receptors are G protein-coupled, possess seven transmembrane domains, and are responsible for detecting odorant molecules in the nose, initiating neuronal responses that trigger the perception of smell[1][3][4][5]. Olfactory receptors are highly diverse, each recognizing different odorants, and work together to facilitate the sense of smell[1][4]. While primarily expressed in the nasal olfactory epithelium, some receptors are found in extranasal tissues, contributing to broader physiological processes and potentially disease mechanisms[5].

Other names
OR14K1OR5AY1OR1-39OR1.5.9
02

Mechanism of action

Not applicable for direct drugs (see above); general mechanism is G protein-mediated transduction of odorant signals

03

Biological functions

Signal transductionRecognition of odorant moleculesInitiation of neuronal response for sense of smell
04

Disease associations

Neurodegenerative disease (by association, as malfunction in olfactory receptor metalloproteins may be related to amyloid-based neurodegenerative diseases)Other (potential involvement in extranasal tissue physiology and diseases)

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