Target intelligence / Profile preview

Olfactory receptor family 2 subfamily AK member 2 (OR2AK2)

Target
OR2AK2
Molecular classification
G protein-coupled receptor (GPCR), Olfactory receptor, Receptor
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Overview

Olfactory receptor family 2 subfamily AK member 2 (OR2AK2) is a member of the large family of olfactory receptors, which are G protein-coupled receptors (GPCRs) expressed primarily in the nasal olfactory epithelium. These receptors have a characteristic 7-transmembrane domain architecture and are responsible for detecting odorant molecules, initiating G protein-mediated signal transduction that leads to the perception of smell. Olfactory receptors are encoded by single coding-exon genes and represent the largest gene family in the human genome. While most OR2AK2 activity is presumed to be in the context of olfaction, some evidence suggests potential, but not well-defined, roles in extranasal tissues. There are no known drugs, biomarkers, or clinical safety concerns related to this receptor.

Other names
OR2AK2OR1-47OR2AK1POlfactory receptor 2AK2Olfactory receptor 2AK1Olfactory receptor OR1-47olfactory receptor, family 2, subfamily AK, member 1 pseudogene
02

Mechanism of action

Not applicable (no known drugs targeting OR2AK2; generally, olfactory receptors initiate G protein-mediated signal transduction upon binding odorant molecules)

03

Biological functions

Signal transductionOdorant recognitionSensory perception of smell
04

Disease associations

Other (OR2AK2 has been associated with Immunodeficiency 40 in the literature, but evidence for its broad disease involvement is limited and its implication as a direct pathological driver is not established)Other (possible roles in extranasal tissues are hypothesized due to tissue expression, but are not well defined)
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Safety considerations

None reported (no therapeutic interventions targeting OR2AK2, so no direct safety concerns are described)
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Interacting drugs

None known (Olfactory receptors in general are not currently established as direct therapeutic drug targets; no specific drugs are reported to interact with OR2AK2)
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Biomarkers

None known (no evidence for use of OR2AK2 as a biomarker for patient selection or efficacy monitoring)

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