Olfactory receptor family 2 subfamily M member 4 (OR2M4)

Olfactory receptor family 2 subfamily M member 4 (OR2M4) is a member of the large family of olfactory receptors, which are G protein-coupled receptors (GPCRs) with a canonical seven-transmembrane domain structure[2][4][5]. These receptors are responsible for the recognition of odorant molecules in the nose and the transduction of this binding event into neuronal signals, which are relayed to the brain as smell perception. The olfactory receptor gene family is the largest in the human genome and is highly diverse, with each receptor exhibiting selectivity for different odorant molecules[1][2][8]. OR2M4 is a protein-coding gene with functional annotation for olfactory receptor activity and is implicated in olfactory signaling pathways[2][8]. Though primarily involved in the sense of smell, some olfactory receptors—potentially including OR2M4—have been reported in non-olfactory tissues, but their physiological significance outside the olfactory epithelium remains largely undefined[6]. There are no known drugs approved or in development that selectively target OR2M4, and its primary biological function is in sensory signal transduction, not as a conventional therapeutic target.

Other names

Olfactory receptor 2M4OR2M4HTPCRX18TPCR100HSHTPCRX18OST710Olfactory receptor OR1-55Olfactory receptor TPCR100novel 7 transmembrane receptor (rhodopsin family) protein

as a member of the olfactory receptor family, therapeutic antagonists/agonists are not established; endogenous mechanism involves odorant binding and G protein activation[1][2]