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Target intelligence / Profile preview
Olfactory receptor family 2 subfamily M member 7 (OR2M7)
- Target
- OR2M7
- Molecular classification
- G protein-coupled receptor, Receptor, Olfactory receptor
01
Overview
Olfactory receptor family 2 subfamily M member 7 (OR2M7) is a member of the large family of olfactory receptors, which are G-protein-coupled receptors responsible for the detection of odorant molecules in the nasal cavity and initiation of the neuronal signal for smell perception[2][3]. OR2M7 shares a seven-transmembrane domain structure characteristic of GPCRs. In humans, OR2M7 genetic variants influence individual abilities to detect particular odors, such as the sulfurous metabolites excreted in urine after eating asparagus. There is no current evidence supporting a therapeutic or disease-related targeting of this receptor; it is involved mainly in sensory perception. Polymorphisms near or within OR2M7 are a biomarker for sensitivity to certain food-related odors[1][3].
- Other names
- Olfactory receptor 2M7OR2M7Olfactory receptor OR1-58OR1-58OR2M7 DOR2M7 NOR2M7 O
02
Biological functions
Odorant detectionSignal transduction
03
Disease associations
Other (variation in olfactory perception; specifically, ability to detect certain odors such as asparagus metabolites in urine)
04
Biomarkers
Genetic variants in OR2M7 are associated with the ability to detect asparagus odor in urine
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