Target intelligence / Profile preview

Olfactory receptor family 2 subfamily T member 33 (OR2T33)

Target
OR2T33
Molecular classification
G protein-coupled receptor, Receptor, Seven-transmembrane domain protein
01

Overview

Olfactory receptor family 2 subfamily T member 33 (OR2T33) is a G protein-coupled receptor involved in the detection of odorant molecules in the nose, initiating neuronal responses that trigger the perception of smell. Like other olfactory receptors, OR2T33 has a seven-transmembrane domain structure characteristic of the rhodopsin family and is encoded by a single coding-exon gene[1][4][5]. Although primarily associated with olfaction, OR2T33 and related receptors are expressed in various non-chemosensory tissues and may play roles in neurological processes, with altered expression observed in neurodegenerative disorders such as Parkinson's disease and dementia with Lewy bodies[2][3]. However, there is no evidence of OR2T33 being a target of approved drugs or having a direct therapeutic application.

Other names
Olfactory receptor 2T33OR1-56OR2T32Olfactory receptor OR1-56novel 7 transmembrane receptor (rhodopsin family) protein
02

Biological functions

Odorant recognitionSignal transduction (neurological)Sensory perception of smell
03

Disease associations

Neurodegenerative diseaseParkinson’s diseaseDementia with Lewy bodies(Other possible roles in neurobiology but not established as direct disease targets)
04

Biomarkers

Altered gene expression (downregulation in Parkinson’s disease substantia nigra, upregulation in dementia with Lewy bodies)[2][3]

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