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Target intelligence / Profile preview
Olfactory receptor family 4 subfamily A member 15 (OR4A15)
- Target
- OR4A15
- Molecular classification
- G protein-coupled receptor (GPCR), Receptor, Transmembrane protein
01
Overview
Olfactory receptor family 4 subfamily A member 15 (OR4A15) is a G protein-coupled receptor present in the human olfactory epithelium. It interacts with odorant molecules in the nose to initiate neuronal signals responsible for the perception of smell. OR4A15 is part of the largest gene family in the human genome and shares a seven-transmembrane domain structure with neurotransmitter and hormone receptors. Its canonical role is in signal transduction for olfactory sensation, acting as a chemosensory receptor. While olfactory receptors are now known to have some nonolfactory physiological roles, OR4A15's characterized function is specific to odor recognition, and it is not currently a known drug target or disease biomarker.
- Other names
- Olfactory receptor 4A15OR4A15Olfactory receptor OR11-118OR11-118
02
Mechanism of action
No therapeutic agents targeting OR4A15; natural activation is through odorant molecule binding and G protein signaling
03
Biological functions
Signal transductionRecognition of odorant moleculesActivation of neuronal response for perception of smell
04
Disease associations
No direct disease role for OR4A15 reported; some olfactory receptors have been linked to nonolfactory physiological processes and may have indirect roles in disease, but this is not established for OR4A15 specifically
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