Olfactory receptor family 4 subfamily A member 16 (OR4A16)

Olfactory receptor family 4 subfamily A member 16 (OR4A16) is a human protein encoded by the OR4A16 gene, functioning as an olfactory receptor. Olfactory receptors are part of the large G protein-coupled receptor (GPCR) family and are characterized by a 7-transmembrane domain structure common to many neurotransmitter and hormone receptors. OR4A16 is involved in recognizing odorant molecules in the nose and initiates neuronal responses that result in the perception of smell. This gene is one of many in the olfactory receptor gene family, the largest family in the human genome, and arises from a single coding exon. There is no evidence that OR4A16 is a therapeutic target or that it interacts with approved drugs, nor are there established disease roles or biomarker applications for this receptor[1][6]. OR4A16 is specifically a member of the GPCR superfamily, with its primary biological role being in the olfactory system, not in disease or therapeutics[1][6]. The aliases listed reflect both nomenclature synonyms and older, parallel assignations in the literature and genomic databases[1][6]. There is no current evidence in cancer biology or other disease settings implicating OR4A16—as opposed to some other olfactory receptors that have extra-nasal roles[2][3]. GPCR mechanisms, such as those in olfactory receptors, generally involve G protein-mediated signaling cascades, but no approved or investigational drugs target OR4A16 specifically[3].

Other names

Olfactory receptor 4A16OR4A16QOlfactory receptor OR11-117OR11-117