Target intelligence / Profile preview

Olfactory receptor family 4 subfamily F member 29 (OR4F29)

Target
OR4F29
Molecular classification
G protein-coupled receptor (GPCR), Receptor, Seven-transmembrane domain protein
01

Overview

Olfactory receptor family 4 subfamily F member 29 (OR4F29) is a protein-coding gene that encodes a member of the olfactory receptor family, which interact with odorant molecules in the nasal epithelium to initiate a neuronal response leading to the perception of smell. OR4F29 belongs to the largest gene family in the human genome and is a representative of G protein-coupled receptors (GPCRs), characterized by a seven-transmembrane domain structure shared with many neurotransmitter and hormone receptors. These receptors detect and transduce odorant signals via G protein-mediated pathways. The primary biological function of OR4F29 is odorant recognition and participation in the olfactory signaling pathway. While GPCRs are major drug targets generally, there are currently no approved drugs or established therapeutic interventions targeting this specific receptor. OR4F29 has associations with some rare development disorders via gene copy number variations but is not directly implicated or targeted in common diseases or therapy

Other names
OR4F3OR4F16Olfactory receptor 4F3Olfactory receptor 4F16Olfactory receptor OR1-1OR7-21Seven transmembrane helix receptor
02

Mechanism of action

Not applicable (no established drugs known to act via this receptor in a therapeutic context)

03

Biological functions

Signal transductionOdorant recognitionG protein-mediated signal transduction
04

Disease associations

Mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformationsCuller-Jones syndrome1p36 copy number variation syndrome (pathway association)
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Safety considerations

None known or reported (no data indicating therapeutic targeting or related safety issues)
06

Interacting drugs

None known or established (olfactory receptors in humans, including OR4F29, do not have documented clinically used drugs targeting them)
07

Biomarkers

None established for patient selection or efficacy monitoring

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