Target intelligence / Profile preview

Olfactory receptor family 4 subfamily L member 1 (OR4L1)

Target
OR4L1
Molecular classification
G protein-coupled receptor (GPCR), Transmembrane receptor
01

Overview

Olfactory receptor family 4 subfamily L member 1 (OR4L1) is a G protein-coupled receptor expressed primarily in the olfactory epithelium and responsible for the recognition and G protein-mediated transduction of odorant signals, initiating neuronal responses that trigger the perception of smell[1][3][6][7]. It shares a seven-transmembrane domain structure with other GPCRs and forms part of the largest gene family in the human genome. Members of this receptor family display broad ligand specificity for odorant molecules; activation of OR4L1 contributes to the molecular basis of olfactory coding but it is not currently implicated in pharmacological targeting nor in common diagnostic or therapeutic applications[1][3].

Other names
Olfactory receptor 4L1OR4L1OR4L2POlfactory receptor 4L2Olfactory receptor OR14-28OR14-28Olfactory receptor, family 4, subfamily L, member 2 pseudogene
02

Mechanism of action

Not applicable (no known drugs; general mechanism involves G protein-mediated signal transduction in response to odorant binding)

03

Biological functions

Signal transductionRecognition of odorants (chemoreception/sensory perception of smell)
04

Disease associations

Other (not clearly associated with major disease phenotypes; associations reported with "Paralytic Squint" and "Hypertropia" in disease databases, but not functionally established as causal)

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