Olfactory receptor family 4 subfamily X member 1 (OR4X1)

Olfactory receptor family 4 subfamily X member 1 (OR4X1) is a protein belonging to the human olfactory receptor gene family, which is the largest in the human genome[1][5]. These receptors mediate the detection of odorant molecules in the nose, initiating a neuronal response that leads to the perception of smell[1][5]. Structurally, OR4X1 possesses seven transmembrane domains typical of G protein-coupled receptors, including several neurotransmitter and hormone receptors[1][5]. Upon binding an odorant, the receptor undergoes a conformational change that activates intracellular G protein signaling pathways, leading to neuronal signaling[1]. The OR4X1 gene is a segregating pseudogene in humans, meaning some individuals possess a functional allele, and others possess a predicted non-functional allele[5]. OR4X1 is not currently considered a direct therapeutic target, and there are no known drugs or established disease associations directly linked to this protein[5]. Its primary recognized function is in the sensory transduction of olfaction. There is no indication that "Olfactory receptor family 4 subfamily X member 1" is an incorrect target or major misnomer, but its status as a pseudogene in some individuals means its protein may not always be functional[5]. There are currently no known drugs or clinical applications targeting OR4X1. The molecular classifications and functions are well-established as those of an olfactory GPCR[1][5].

Other names

Olfactory receptor 4X1OR4X1Olfactory receptor OR11-104OR11-104Olfactory receptor, Family 4, Subfamily X, Member 1