Olfactory receptor family 5 subfamily B member 12 (OR5B12)

Olfactory receptor family 5 subfamily B member 12 (OR5B12) is a human G protein-coupled receptor (GPCR) expressed in the nasal epithelium, where it interacts with airborne odorant molecules to initiate the neuronal signaling necessary for the perception of smell[1][2][6]. These receptors belong to the largest gene family in the human genome and are defined by a characteristic 7-transmembrane domain architecture shared with many neurotransmitter and hormone receptors[1][2][7]. The receptor mediates G protein-dependent signal transduction following odorant recognition, leading to membrane depolarization and sensory neuron activation[1][2]. The nomenclature for olfactory receptors is independent across species, and while related paralogs and pseudogenes exist, OR5B12 primarily functions for olfaction; there is no current evidence of its role in disease or pharmacology[1][2][5][6].

Other names

OR5B12OR11-241OR5B12POR5B16OST743Olfactory receptor family 5 subfamily B member 12 pseudogeneOlfactory receptor family 5 subfamily B member 16Olfactory receptor, family 5, subfamily B, member 12Olfactory receptor, family 5, subfamily B, member 16Olfactory receptor OR11-241Olr343Olfr1448MOR202-5