Target intelligence / Profile preview

Olfactory receptor family 5 subfamily D member 13 (OR5D13)

Target
OR5D13
Molecular classification
G protein-coupled receptor, Receptor, 7-transmembrane domain protein
01

Overview

Olfactory receptor family 5 subfamily D member 13 (OR5D13) is a member of the large olfactory receptor family of G protein-coupled receptors (GPCRs), characterized by a 7-transmembrane domain structure[1][2][3][4]. OR5D13 binds odorant molecules in the nose, initiating a neuronal response via G protein-mediated signal transduction that leads to the perception of smell[1][2][3][5]. These receptors are encoded by single coding-exon genes, and the olfactory receptor gene family constitutes the largest gene family in the human genome[1][3]. The OR5D13 gene is considered a segregating pseudogene: some individuals possess a functional allele, while others have a non-functional version[1][3]. OR5D13 may have roles beyond olfaction, but primary function is odorant detection[4]. There are no known drugs directly targeting OR5D13, nor is it a major therapeutic target outside its sensory function[1][3][4].

Other names
Olfactory receptor 5D13OR5D13Olfactory receptor OR11-142Olfactory receptor OR11-148
02

Biological functions

Signal transductionOdorant bindingInitiation of olfactory neuronal response (smell perception)
03

Disease associations

Reported association with hyaline fibromatosis syndrome[1]

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