Olfactory receptor family 5 subfamily D member 18 (OR5D18)

Olfactory receptor family 5 subfamily D member 18 (OR5D18) is a human protein-coding gene encoding a receptor that interacts with odorant molecules in the nose, initiating a neuronal response to trigger the perception of smell. It is part of the largest gene family in the human genome and belongs to the G protein-coupled receptor (GPCR) superfamily, characterized by a seven transmembrane domain structure like many neurotransmitter and hormone receptors. OR5D18 is involved in the recognition and transduction of odorant signals through G protein-mediated pathways; the canonical pathway involves the activation of adenylyl cyclase and subsequent cAMP signaling. The gene does not have established roles in disease nor identified drug interactions and is a representative member of olfactory receptors responsible for the diversity of human olfactory perception

Other names

Olfactory receptor 5D18OR5D18Olfactory receptor OR11-143Olfactory receptor OR11-152OR11-143OR11-152

Not applicable for approved pharmacological agents. If targeted, mechanism would involve modulation of odorant binding and downstream G protein-mediated signaling