Target intelligence / Profile preview

Olfactory receptor family 5 subfamily H member 1 (OR5H1)

Target
OR5H1
Molecular classification
G protein-coupled receptor, Receptor, Olfactory receptor
01

Overview

Olfactory receptor family 5 subfamily H member 1 (OR5H1) is a human protein encoded by the OR5H1 gene. It is a member of the large family of G protein-coupled receptors (GPCRs) found in the nasal epithelium and is responsible for the detection and signal transduction of odorant molecules. Like all olfactory receptors, OR5H1 has seven transmembrane domains and initiates a G protein-mediated signaling pathway upon odorant binding, resulting in neuronal activation and the perception of smell. OR5H1 is not associated with any disease or therapeutic interventions and is not a target for clinical drugs[4][6][8][9].

Other names
OR5H1Olfactory receptor 5H1HTPCRX14HSHTPCRX14
02

Mechanism of action

Not applicable for pharmacological agents, but physiologically: recognizes odorant (volatile) molecules, activates G protein-coupled cascade, leads to neuronal response signaling smell perception[6][8][9].

03

Biological functions

Detection of chemical stimulus involved in sensory perception of smell[6]Signal transduction
04

Disease associations

None known (no established role in cancer, inflammation, neurodegeneration, cardiovascular disease, or infection)
05

Safety considerations

None known or reported
06

Interacting drugs

None known (this receptor does not have any established drug ligands; primarily binds to odorant molecules such as volatile chemicals associated with smell)[4][6][8][9]
07

Biomarkers

None established

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