Olfactory receptor family 5 subfamily L member 1 (OR5L1)

Olfactory receptor family 5 subfamily L member 1 (OR5L1) is a member of the large family of G protein-coupled receptors involved in the detection of odorant molecules in the nose, initiating neuronal responses that trigger the perception of smell. Like other olfactory receptors, OR5L1 is encoded by a single coding-exon gene and possesses a characteristic 7-transmembrane domain structure found in many neurotransmitter and hormone receptors. OR5L1 is noted as a “segregating pseudogene,” meaning that in some individuals it encodes a functional receptor, whereas in others the encoded protein is predicted to be non-functional. The primary function of OR5L1, as with other olfactory receptors, is implicated in the olfactory signaling pathway, where its activity relates to odor detection and signal transduction. Key points: - OR5L1 is a bona fide G protein-coupled receptor of the olfactory receptor family. - Its main annotated roles are in sensory signal transduction (smell). - It is not a major therapeutic target, and there are no approved or well-known drugs targeting this specific receptor. - Some allelic forms may be nonfunctional; overall, its status is best described as a canonical olfactory receptor with limited evidence for disease association outside of olfaction.

Other names

Olfactory receptor 5L1OST262Olfactory receptor OR11-151OR11-151