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Target intelligence / Profile preview
Olfactory receptor family 5 subfamily M member 3 (OR5M3)
- Target
- OR5M3
- Molecular classification
- G protein-coupled receptor (GPCR), Receptor, Odorant receptor
01
Overview
Olfactory receptor family 5 subfamily M member 3 (OR5M3) is a human protein encoded by the OR5M3 gene. It is a member of the olfactory receptor family of class A G protein-coupled receptors (GPCRs), characterized by a seven-transmembrane domain structure. OR5M3 is expressed in the nasal olfactory epithelium, where it binds odorant molecules and initiates G protein-mediated signal transduction, leading to neuronal responses that enable the perception of smell. Olfactory receptors, including OR5M3, originate from single coding-exon genes, and the family is the largest in the human genome. Like other olfactory receptors, OR5M3 does not have established roles in nonolfactory diseases or as a drug target, though the broader olfactory receptor family has emerging relevance in extranasal tissues.
- Other names
- Olfactory receptor 5M3OR5M3Olfactory receptor OR11-191OR11-191OR5M3_HUMANHGNC:14806NCBI Gene:219482ENSG00000174937
02
Mechanism of action
Not applicable / unknown — There are no available data describing the molecular pharmacology or drug mechanism of action for agents affecting OR5M3
03
Biological functions
Signal transductionOdorant bindingInitiation of neuronal response for sense of smell
04
Disease associations
While olfactory receptors as a family have been broadly implicated in nonolfactory physiological processes and may play roles in diseases, specific disease roles for OR5M3 itself are not described in the literature to date
05
Safety considerations
None reported — No direct safety concerns or therapeutic challenges have been described for OR5M3
06
Interacting drugs
No known approved drugs or investigational agents directly targeting OR5M3 are listed in biomedical or drug databases as of June 2024
07
Biomarkers
None known — OR5M3 is not used as a diagnostic or efficacy biomarker in clinical practice
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