Olfactory receptor family 5 subfamily P member 3 (OR5P3)

Olfactory receptor family 5 subfamily P member 3 (OR5P3) is a G protein-coupled receptor expressed in the olfactory epithelium, where it initiates the neuronal response upon binding to odorant molecules, triggering the perception of smell. Like all olfactory receptors, it possesses a 7-transmembrane domain structure and is part of the largest gene family in the human genome. OR5P3, along with other olfactory receptors, mediates signal transduction via G protein activation, converting extracellular odorant detection into intracellular signaling (primarily via cAMP pathway). There is limited evidence for a disease association or druggability, and no known marketed drugs target this receptor directly.

Other names

Olfactory receptor 5P3JCG1Olfactory receptor OR11-94Olfactory receptor-like protein JCG1OR5P3_HUMANGene IDs: HGNC:14784, NCBI Gene:120066, UniProt:Q8WZ94

Odorant ligand binding leads to activation of the G protein-mediated signal transduction pathway