Target intelligence / Profile preview

Olfactory receptor family 52 subfamily B member 2 (OR52B2)

Target
OR52B2
Molecular classification
G protein-coupled receptor, Receptor, Olfactory receptor, Rhodopsin-like class A GPCR
01

Overview

Olfactory receptor family 52 subfamily B member 2 (OR52B2) is an odorant receptor encoded by the OR52B2 gene in humans. It is a member of the G protein-coupled receptor (GPCR) superfamily, specifically within the rhodopsin-like class A GPCRs. OR52B2 is a single-exon gene and, like other olfactory receptors, features a seven-transmembrane domain structure. This receptor is responsible for recognizing specific odorant molecules in the nasal epithelium, leading to G protein-mediated signal transduction that initiates the perception of smell. OR52B2 is one of the large repertoire of olfactory receptors in the human genome, which collectively enable the detection and discrimination of a vast number of odorant molecules. No known direct roles for OR52B2 have been established in specific diseases or as a drug target, and there are currently no drugs or clinical biomarkers involving this receptor.

Other names
Olfactory receptor 52B2OR52B2Olfactory receptor OR11-70OR11-70olfactory receptor 52B2olfactory receptor OR11-70
02

Biological functions

Odorant recognitionSignal transduction (via G proteins)Initiation of olfactory (smell) perception
03

Disease associations

Other (no direct disease association, but olfactory receptors as a group may have unexplored roles)Dihydropyrimidinase deficiency (noted as an associated disease but likely indirect or genomic/neighbor effect)3-Methylglutaconic aciduria, type I (as above; see note)

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