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OR52E3P (“Olfactory receptor family 52 subfamily E member 3 pseudogene”) is annotated as a human pseudogene and not a protein-coding gene[1][2]. It belongs to the olfactory receptor family, which consists largely of G protein-coupled receptors (GPCRs) involved in detecting odorants; however, as a pseudogene, OR52E3P does not encode a functional receptor[1]. Pseudogenes are nonfunctional DNA sequences arising from mutations in protein-coding genes, and olfactory receptor gene families contain many such pseudogenes due to low evolutionary pressure for maintaining redundant or unnecessary olfactory receptors[4]. There is no evidence for direct involvement in biological functions, disease associations, or therapeutic drug interactions for OR52E3P, distinguishing it from functional GPCRs and olfactory receptors.
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