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Target intelligence / Profile preview
Olfactory receptor family 52 subfamily E member 4 (OR52E4)
- Target
- OR52E4
- Molecular classification
- G protein-coupled receptor, Receptor, Rhodopsin-like class A GPCR, Seven-transmembrane domain receptor
01
Overview
Olfactory receptor family 52 subfamily E member 4 (OR52E4) is a member of the G protein-coupled receptor superfamily characterized by seven transmembrane domains. It is specifically involved in the initial detection of odorant molecules in the human olfactory epithelium. The binding of odorants to OR52E4 induces a conformational change that activates a G protein-dependent signaling cascade, ultimately resulting in the neuronal perception of smell. The olfactory receptor gene family is the largest in the human genome, and OR52E4 is classified within the class A (rhodopsin-like) GPCRs. No specific disease associations, drugs, or biomarkers have been currently identified for OR52E4, and its primary role is in sensory signal transduction.
- Other names
- OR52E4OR11-55Olfactory receptor OR11-55HsOR11.3.87
02
Mechanism of action
Ligand (odorant molecule) binding triggers conformational changes that activate G protein-mediated signaling.
03
Biological functions
Signal transductionRecognition and transduction of odorant signalsSensory perception of smell
04
Disease associations
Other (No well-established disease associations for OR52E4 specifically; olfactory receptors as a group may have roles in sensory deficits.)
05
Safety considerations
None noted; olfactory receptors are not therapeutically targeted, so major safety challenges are not reported.
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