Olfactory receptor family 52 subfamily E member 5 (OR52E5)

Olfactory receptor family 52 subfamily E member 5 (OR52E5) is a G protein-coupled receptor found in the olfactory epithelium, where it recognizes specific odorant molecules and triggers neuronal signaling that leads to smell perception. Like other olfactory receptors, OR52E5 has a 7-transmembrane domain architecture shared by neurotransmitter and hormone receptors. It is classified within the largest gene family in the human genome, responsible for detecting a wide variety of chemical stimuli. OR52E5 is part of the class A GPCRs and specifically binds odorants, likely recognizing carboxylic acid odorants with long hydrocarbon tails, based on structural analysis of closely related family members. This gene is located on chromosome 11 (11:5,900,777-5,901,757) and is conserved across species, with paralogs and orthologs identified in mouse, rat, and other mammals. The classification as a "pseudogene" in some informatics resources is inconsistent with functional annotation in major databases (GENECARDS, UniProt, NCBI), which list it as a protein-coding gene. Overall, OR52E5 is a GPCR involved in odor detection and signal transduction in the olfactory system, with no evidence for direct therapeutic relevance or drug interaction outside its physiological role.

Other names

OR52E5OR11-56HsOR11.3.88ORL3294olfactory receptor 52E5olfactory receptor OR11-56 pseudogene

For odorants: binding to the receptor activates G protein-coupled signaling leading to neuronal activation and perception of smell