Olfactory receptor family 52 subfamily H member 2 pseudogene (OR52H2P)

Olfactory receptor family 52 subfamily H member 2 pseudogene (OR52H2P) is classified as a pseudogene and does not encode a functional protein[1][3]. Olfactory receptor genes code for G protein-coupled receptors responsible for detecting odorants and initiating neuronal responses that result in the perception of smell, but pseudogenes such as OR52H2P carry sequence disruptions (such as nonsense mutations or frame shifts) that prevent them from producing functional proteins[1][3]. While most olfactory receptor pseudogenes are presumed non-functional, recent research has revealed that some “pseudo-pseudogenes” in animal species can retain functionality through mechanisms such as translational readthrough, but there is no evidence that the human OR52H2P gene produces a functional protein[2][5]. OR52H2P remains part of the large olfactory receptor gene family, the largest in the human genome, but is not regarded as a therapeutic target due to its lack of demonstrated functional protein product or involvement in disease[1][3].\n\nNotes:\n- As a pseudogene, OR52H2P is not a therapeutic target, does not encode a functional protein, and has no known disease roles, biomarkers, or interacting drugs.\n- “Olfactory receptor family 52 subfamily H member 2 pseudogene” is the full canonical name per current gene nomenclature conventions[1][3].

Other names

OR52H2Polfactory receptor, family 52, subfamily H, member 2 pseudogene