Olfactory receptor family 52 subfamily W member 1 (OR52W1)

Olfactory receptor family 52 subfamily W member 1 (OR52W1) is a member of the olfactory receptor (OR) family, which comprises G protein-coupled receptors (GPCRs) involved in the recognition of odorant molecules in the nose and the initiation of neuronal signaling that leads to the perception of smell[2][3][7]. Olfactory receptors share a 7-transmembrane domain structure typical of class A GPCRs and function primarily in the olfactory epithelium, though some evidence indicates extranasal expression for the receptor class in general[5]. OR52W1 is a protein-coding gene in humans but is also annotated as a pseudogene (OR52W1P) in some sources, which may indicate lack of functional protein expression or gene inactivity in certain populations[2][3]. No currently approved drugs are known to target OR52W1, and its role in disease is not well established, although generic olfactory receptors have been implicated in rare syndromes such as Bardet-Biedl syndrome 9[3]. It is not considered a therapeutic target at present. Notes on curation and correctness: - OR52W1 is often described as a "pseudogene" and does not have documented drug interactions, biomarker status, or established therapeutic use[2][3]. - Functional olfactory GPCRs are studied as a family for their structural features and transduction mechanisms but individual ORs like OR52W1 are not typically drug targets or involved directly in disease pathways[1][4][5]. - "Is_incorrect" is true because OR52W1 may be a gene with pseudogene status in many contexts and is not a validated or commonly pursued therapeutic target. - OR52W1 and OR52W1P refer to the same genomic locus; "P" indicates a pseudogene form[2][3]. - Some descriptions group OR52W1 with related receptor families and paralogs (e.g., OR52L1), but the family is large (~400 genes in humans)[1][3].

Other names

Olfactory receptor 52W1OR52W1OR52W1POlfactory receptor OR11-71OR11-71olfactory receptor, family 52, subfamily W, member 1 pseudogene