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Olfactory receptor family 6 subfamily C member 65 (OR6C65) is a G protein-coupled receptor (GPCR) involved in the recognition of odorant molecules in the nose and the initiation of neuronal responses that lead to the perception of smell. OR6C65 is part of the largest gene family in the human genome and possesses a canonical seven transmembrane domain structure characteristic of GPCRs, enabling it to detect and transduce chemical signals via G protein-mediated pathways. Although olfactory receptors are generally localized in the nasal epithelium, and their primary biological function is odor detection, OR6C65 has been cataloged as a protein-coding gene with identified homologs but has no known interactions with therapeutic drugs or clear mechanistic roles in disease. Some studies associate its locus with conditions such as atrial septal defect 9 and autism spectrum disorder, but causative or functional implications remain unproven[5][1]. This molecule is not known to be a validated therapeutic target for drug development, and no biomarkers or safety concerns have been established in the literature[5][1].
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