Olfactory receptor family 6 subfamily J member 1 (OR6J1)

Olfactory receptor family 6 subfamily J member 1 (OR6J1) is a member of the large olfactory receptor gene family in humans, which encodes G protein-coupled receptors responsible for detecting odorant molecules and initiating neuronal responses that result in the perception of smells. OR6J1 has the typical 7-transmembrane domain architecture of GPCRs and is expressed in the olfactory epithelium. Like many olfactory receptors, it is a segregating pseudogene in some humans—meaning some individuals have a functional allele, while in others the gene is nonfunctional. The main biological function of OR6J1, when functional, is mediating odorant signaling via G protein-coupled activation and resulting neuronal transduction. There are no known drugs that specifically target OR6J1, and this type of receptor is not considered a common disease target outside of rare associations with sensory phenotypes or exome/genome sequencing discoveries[3][4][2][5]. Additional Details: - OR6J1 is referenced in genome resources and databases (HGNC: 14707; NCBI Gene: 79549; Ensembl: ENSG00000255804; UniProt: Q8NGC5)[3]. - Paralogs: OR6M1 is a closely related paralog[3][6]. - Most functional information about olfactory receptors comes from studies of family members with strong expression or known odorant ligands; many, including OR6J1, lack detailed ligand specificity data in current literature[3][5]. - The olfactory receptor family as a whole is the largest gene family in the human genome, with a predominance of genes and pseudogenes reflecting rapid evolutionary change[3][5].

Other names

Olfactory receptor 6J1OR6J2olfactory receptor, family 6, subfamily J, member 2OR6J1Polfactory receptor 6J2seven transmembrane helix receptor