Target intelligence / Profile preview

Olfactory receptor family 6 subfamily K member 3 (OR6K3)

Target
OR6K3
Molecular classification
G protein-coupled receptor, Receptor, Olfactory receptor, Rhodopsin-like GPCR (7-transmembrane domain receptor)
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Overview

Olfactory receptor family 6 subfamily K member 3 (OR6K3) is a human G protein-coupled receptor (GPCR) gene encoding a member of the olfactory receptor family, primarily expressed in olfactory sensory neurons of the nasal epithelium[2][6]. Olfactory receptors like OR6K3 are responsible for the recognition of odorant molecules, initiating G protein-mediated signal transduction that triggers the perception of smell. These receptors share a characteristic seven-transmembrane domain structure common to rhodopsin-like GPCRs[2][6]. OR6K3 is a single-exon gene located on chromosome 1[3]. While olfactory receptors are also found in some non-chemosensory tissues, their primary biological role remains in chemosensation, and there are no established specific disease associations, interacting drugs, or biomarker uses for OR6K3[1][2][6].

Other names
Olfactory receptor 6K3OR6K3Olfactory receptor OR1-18OR1-18Seven transmembrane helix receptor OR6K3 (less common; note, this is a structural description rather than a widely used alias)
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Mechanism of action

Not applicable (for drugs, as there are no known drugs targeting this specific receptor)

03

Biological functions

Signal transductionRecognition of odorants (chemical sensing)G protein-coupled receptor signaling pathway
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Disease associations

Other (some olfactory receptors are differentially expressed in neurodegenerative diseases, but OR6K3 itself is not specifically linked to a major disease)
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Safety considerations

None specifically documented; as an odorant receptor, direct safety concerns or therapeutic challenges are not established
06

Interacting drugs

None known (as of current knowledge, no approved drugs or investigational compounds directly target OR6K3)
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Biomarkers

None established for patient selection or efficacy monitoring

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