Olfactory receptor family 7 subfamily C member 2 (OR7C2)

Olfactory receptor family 7 subfamily C member 2 (OR7C2) is a 7-transmembrane domain G protein-coupled receptor located in the nasal olfactory epithelium, where it interacts with odorant molecules to initiate neuronal responses leading to the perception of smell[2][4][5]. The OR7C2 protein arises from a single coding-exon gene and belongs to the rhodopsin-like (Class A/1) GPCR superfamily, responsible for odor recognition and G protein-mediated signal transduction. Although primarily functioning in sensory physiology, olfactory receptors may be expressed in other tissues, albeit with unclear pathological roles[5]. OR7C2 shares canonical GPCR features, including a conserved 7-transmembrane domain architecture used for G protein signaling[2][4][5]. The protein’s primary mechanism is odor-binding and coupling to G proteins, leading to the activation of downstream signaling pathways[2][5]. Antibodies and gene knockdown reagents are available for OR7C2, facilitating research on structure, localization, and function in humans and select other mammals[2][5]. No evidence suggests errors or ambiguity in the target’s name, classification, or scientific context; however, there is limited information about its disease association and no direct drug targeting known to date[2][4][5].

Other names

OR7C2olfactory receptor 7C2OR19-18OR7C3 (Older HGNC annotation)