Olfactory receptor family 7 subfamily E member 160 pseudogene (OR7E160P)

Olfactory receptor family 7 subfamily E member 160 pseudogene (OR7E160P, ENSG00000254817) is a pseudogene in the human genome that arose from a member of the olfactory receptor gene family, a large family of G protein-coupled receptors (GPCRs) involved in the detection of odorant molecules and initiation of smell perception[3][1]. While functional olfactory receptors are responsible for transducing odorant signals, this specific locus is classified as a pseudogene, meaning it is predicted to be non-functional and does not produce a functional protein in humans[3][1]. The existence of olfactory receptor pseudogenes is typical and reflects the evolutionary decrease in selective pressure for maintaining some olfactory functions in primates, especially humans[6]. No therapeutic role, disease association, or drug interaction is reported for this gene; it is not considered a therapeutic or research target. Note: Rarely, some organisms possess “pseudo-pseudogenes”—genes annotated as pseudogenes but which retain protein function through mechanisms like translational readthrough[2][4][5]. However, there is no evidence that ENSG00000254817 is such a functional pseudogene in humans.

Other names

OR7E160Polfactory receptor, family 7, subfamily E, member 160 pseudogene

None known