Olfactory receptor family 8 subfamily B member 3 pseudogene

Olfactory receptor family 8 subfamily B member 3 pseudogene (ENSG00000254937; also known as LOC100421985) is a human olfactory receptor pseudogene that arises from a gene duplication or mutation event resulting in a non-functional DNA sequence. Olfactory receptors themselves are members of the G protein-coupled receptor (GPCR) superfamily and are normally responsible for detection of odorant molecules, but pseudogenes within these families do not produce functional proteins, due either to nonsense or frameshift mutations that disrupt coding potential. There is no evidence that this specific pseudogene has any functional or regulatory role, or involvement in disease. It is not considered a drug target or biomarker. There is nothing to suggest functional protein is produced from this locus in humans. Note: This entry is not a protein-coding gene and not a functional therapeutic target. As a classical pseudogene, it is included in databases for genomic annotation completeness but not for therapeutic relevance. Based on gene nomenclature, there is no standard abbreviated name widely accepted for this locus, though "OR8B3P" may appear in some contexts, following olfactory receptor gene conventions. References point to olfactory receptor pseudogenes being common in the genome, reflecting low evolutionary pressure to retain function for receptors not needed by the species. There is no evidence of drugs, biomarkers, disease relevance, or safety implications for this specific pseudogene. If you require a protein-coding, functional olfactory receptor, you should select a non-pseudogene member of the family, such as "Olfactory receptor family 8 subfamily B member 3" (without the "pseudogene" designation).

Other names

ENSG00000254937LOC100421985OR8B3P (by analogy to olfactory receptor gene nomenclature expectations)Olfactory receptor, family 8, subfamily B, member 3 pseudogene