Olfactory receptor family 8 subfamily G member 1 (OR8G1)

Olfactory receptor family 8 subfamily G member 1 (OR8G1) is a member of the olfactory receptor family, the largest family of G protein-coupled receptors (GPCRs) in the human genome. OR8G1 encodes a receptor with a 7-transmembrane domain structure responsible for recognizing odorant molecules in the nose and triggering the perception of smell via G protein-mediated transduction. This gene is classified as a polymorphic pseudogene: some individuals possess a functional allele that encodes the full-length protein, while others have a non-functional allele due to an early stop codon and a 3' end deletion. Olfactory receptors are primarily responsible for chemosensation in the nasal olfactory epithelium. There is increasing evidence that olfactory receptors, in general, can be expressed in non-olfactory tissues and may have physiological and possibly pathological roles outside of smell, though no disease or drug interaction is reported specifically for OR8G1.

Other names

Olfactory receptor 8G1OR8G1PTPCR25HSTPCR25Olfactory receptor OR11-281olfactory receptor, family 8, subfamily G, member 1 pseudogene

Not established for any drug; general GPCR/odorant binding and G protein-mediated signal transduction