Olfactory receptor family 8 subfamily G member 3 (OR8G3)

Olfactory receptor family 8 subfamily G member 3 (OR8G3, also named OR8G3P) is annotated bioinformatically as a member of the human olfactory receptor gene family, which encodes G protein-coupled receptors responsible for the detection of odorants in the nasal epithelium[3][7][8]. Most olfactory receptor genes are single-exon, seven-transmembrane domain proteins and make up the largest family of GPCRs in the human genome[3][8]. While well-characterized olfactory receptors transduce chemical odorant signals through G protein–mediated pathways, there is no reported evidence that OR8G3 is functionally expressed as a receptor protein in the human body, nor is it established as a drug target, biomarker, or disease-associated molecule. The alternative names OR8G3P, “putative olfactory receptor 8G3 pseudogene,” and “olfactory receptor family 8 subfamily G member 3 pseudogene” indicate likely classification as a pseudogene (nonfunctional genomic sequence resembling a gene), which is common for many olfactory receptor loci. #### Key points: - **OR8G3 is most likely a pseudogene** (nonfunctional in humans); it is not a validated protein-coding olfactory receptor and has no established physiological or therapeutic roles. - There are currently **no known drugs, biomarkers, or therapeutic safety concerns** associated with OR8G3. - Its **molecular family context** (olfactory receptors/G protein-coupled receptors) is well understood, but this does **not imply functional protein** in the case of pseudogenes. - Its **aliases** and gene models reflect both its original status as a putative receptor and the more current understanding that many such genes are inactive in humans[3][7][8]. If you need information for a **functional human olfactory receptor**, choosing a locus with protein expression and experimental evidence (such as OR51E2 or OR8H3) is recommended.

Other names

Olfactory receptor 8G3OR8G3OR8G3POlfactory receptor OR11-297Olfactory receptor family 8 subfamily G member 3 pseudogenePutative olfactory receptor 8G3 pseudogene

Not applicable