Olfactory receptor family 8 subfamily I member 2 (OR8I2)

Olfactory receptor family 8 subfamily I member 2 (OR8I2) is a protein encoded by the OR8I2 gene in humans and serves as an odorant receptor within the olfactory system. It is classified as a G protein-coupled receptor (GPCR) and has a characteristic 7-transmembrane domain structure common to neurotransmitter and hormone receptors[2][3][4][6][8]. OR8I2 detects specific odorant molecules in the nasal cavity, initiating a neuronal response that triggers the perception of smell. The olfactory receptor proteins represent the largest receptor family in the human genome and function by activating G protein signaling pathways resulting in cAMP production, mediating the signal transduction for odor detection[3][7][8]. Disease associations are limited and largely based on gene locus mapping rather than well-established direct pathophysiological mechanisms[3]. There are no clinically approved drugs that target OR8I2, nor is it recognized as a biomarker or associated with notable safety concerns for therapeutic modulation.

Other names

Olfactory receptor 8I2OR8I2Olfactory receptor OR11-170OR11-170olfactory receptor 8I2olfactory receptor OR11-170

G protein-mediated transduction upon odorant binding