Olfactory receptor family 8 subfamily I member 4 pseudogene (OR8I4P)

Olfactory receptor family 8 subfamily I member 4 pseudogene (OR8I4P) is a pseudogene of an olfactory receptor and is not believed to encode a functional protein[1][2]. Olfactory receptors, when functional, are members of the G protein-coupled receptor (GPCR) family involved in the detection of odorant molecules in the nose, initiating neuronal responses for the sense of smell[1][4]. However, pseudogenes like OR8I4P have lost their protein-coding ability, typically due to nonsense or frameshift mutations, and therefore do not produce functional receptor proteins[3][5]. While some pseudogenes in other species can occasionally exhibit regulatory or rare functional roles, no evidence suggests OR8I4P functions as a therapeutic or physiologically relevant target in humans[1][3][5]. As a pseudogene, OR8I4P is considered non-functional and thus not a therapeutic target[1][2][5]. The human genome contains a high proportion of olfactory receptor pseudogenes, consistent with reduced olfactory capabilities in humans compared to other mammals[5]. There is no established association with drugs, mechanisms of action, utility as biomarker, or disease relevance for this specific pseudogene[1][2]. Aliases include "olfactory receptor, family 8, subfamily I, member 4 pseudogene" and "OR8I4P"[1][2]. No evidence indicates any error in spelling or identification, but it is flagged as "incorrect" in the context of therapeutic targets due to its pseudogene nature (not an actual or potential therapeutic target)[1][2][5].

Other names

OR8I4Polfactory receptor, family 8, subfamily I, member 4 pseudogene