Olfactory receptor family 8 subfamily L member 1 pseudogene (OR8L1P)

Olfactory receptor family 8 subfamily L member 1 pseudogene (OR8L1P) is a human gene classified as a pseudogene, meaning it is a non-functional relative of a gene that encodes an olfactory receptor, specifically in the family 8, subfamily L[2][4][6]. Although it shares sequence homology with olfactory receptor genes, it lacks evidence for protein-coding capability and does not produce a functional receptor protein. Olfactory receptors are a large family of G protein-coupled receptors primarily responsible for detecting odorants in the nasal epithelium and contributing to the sense of smell; however, OR8L1P is not known to perform this function or to have a role in signal transduction[5][7]. There are no known drug interactions, disease associations, biomarker uses, or safety concerns related to this gene. Alternative names for this pseudogene include OR11-115 and HsOR11.11.64P[2][4][6]. Key details: - **Genomic locus**: Chromosome 11 (chr11:56,381,635-56,382,589, GRCh38)[2]. - **Classification as a pseudogene**: It does not encode a functional receptor protein and is not transcribed or translated into a functional product[2][7]. - **Functional olfactory receptors**: These are part of the class A (rhodopsin-like) G protein-coupled receptor superfamily and directly participate in odorant signal transduction[5]; however, OR8L1P does not produce a functional receptor. - **Relevance**: OR8L1P serves as a representative member of the large fraction of the human olfactory receptor gene repertoire that has become pseudogenized during primate evolution[5].

Other names

OR11-115HsOR11.11.64PORL3519

None