Olfactory receptor family 9 subfamily H member 1 pseudogene (OR9H1)

The olfactory receptor family 9 subfamily H member 1 pseudogene (OR9H1) is a human gene identified as a pseudogene within the olfactory receptor (OR) superfamily. While olfactory receptors are typically G protein-coupled receptors involved in odorant detection, OR9H1 contains mutations rendering it nonfunctional and is not involved in the canonical olfactory pathway. The gene shares sequence homology with functional olfactory receptors, and its designation as a pseudogene means it lacks the ability to produce a full-length, functional receptor protein. As such, it does not participate in odor recognition or signal transduction[4][5]. There is no evidence of its involvement in disease, no therapeutic targeting, nor any use as a biomarker. The designation “seven transmembrane helix receptor” refers to its homology rather than its activity, as the protein product—if expressed at all—is truncated or mutated and thus inactive. OR9H1 is notable for being part of the large repertoire of human olfactory receptor pseudogenes, highlighting the evolutionary loss of olfactory receptor function in humans[4][5].

Other names

OR9H1PUNQ9373Olfactory receptor OR9H1VNFT9373Olfactory receptor, family 9, subfamily H, member 1 pseudogeneSeven transmembrane helix receptorOR9H1

None (No mechanism of drug action can be ascribed as it is nonfunctional)