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Olfactory receptor family 9 subfamily N member 1 pseudogene (OR9N1P)

Target: OR9N1P
Molecular classification: Pseudogene, Belongs to the olfactory receptor gene family, which in general consists of G protein-coupled receptors (GPCRs), but this specific entry is nonfunctional

Overview

OR9N1P (Olfactory receptor family 9 subfamily N member 1 pseudogene) is a human pseudogene located on chromosome 7 and is a member of the large olfactory receptor family. Unlike functional olfactory receptor genes, it does *not* encode a protein capable of odorant recognition or signal transduction. Olfactory receptor pseudogenes persist in the genome due to low selection pressure to maintain function, and there is no current evidence of functional RNAs or proteins derived from this locus in humans. The canonical olfactory receptor proteins are G protein-coupled receptors responsible for smell sensation; however, OR9N1P annotation and evidence indicate it represents a nonfunctional remnant of such a gene. There are rare cases of "pseudo-pseudogenes" with unexpected function in other species, but no such phenomenon has been reported for OR9N1P in humans.

Other names: ORL3198GC07U990308 (previous identifier)HGNC: 15096, NCBI Gene: 81383, Ensembl: ENSG00000244292 (external references)Multiple previous GeneCards identifiers (GC07P#####, see source for complete list)

Mechanism of action

Not applicable. Drug mechanism of action is only relevant for functional protein products, not pseudogenes

Biological functions

No known function. By current annotation and evidence, this locus does not encode a functional protein and does not contribute to biological signal transduction or olfactory signaling in humans.Functional olfactory receptor genes mediate odorant recognition and signal transduction but pseudogenes do not participate in these processes

Disease associations

None described. Pseudogenes generally lack disease association unless otherwise noted, and no role is described for OR9N1P in any human disease

Safety considerations

None known. Drug safety concerns relate to functional protein targets, which is not relevant to pseudogenes like OR9N1P

Interacting drugs

None. No drugs are known or reported to interact with OR9N1P, as it does not code for a functional receptor or protein target

Biomarkers

None reported. OR9N1P is not used as a biomarker for patient selection or monitoring

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