Target intelligence / Profile preview

Oligodendrocyte Myelin Glycoprotein

Molecular classification: GPI-linked membrane protein

Overview

Oligodendrocyte myelin glycoprotein (OMgp) is a glycosylphosphatidylinositol (GPI)-anchored protein expressed by both neurons and oligodendrocytes in the central nervous system (CNS). OMgp inhibits neurite outgrowth and regulates cell proliferation, primarily through interaction with Nogo receptor 1 (NgR1). It may also be important for formation and maintenance of CNS myelin sheaths.

Mechanism of action

Inhibition of NgR1 signaling

Biological functions

Inhibits neurite outgrowthRegulates cell proliferationMyelination

Disease associations

Neurodegenerative diseaseCNS trauma

Safety considerations

Inhibition of axonal regeneration

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