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Oligodendrocyte Precursor Cell Surface Antigen (None)

Target: None
Molecular classification: Glycolipid, Sulfatide

Overview

O4 is a cell surface antigen (specifically, a sulfatide) expressed on oligodendrocyte progenitor cells (OPCs) in the central nervous system. It serves as an early and specific marker for cells committed to the oligodendroglial lineage, indicating a transitional stage between undifferentiated precursors and fully differentiated myelinating oligodendrocytes. O4 is commonly used to identify and isolate OPCs for research purposes, allowing the study of CNS development, remyelination, and responses to therapeutic interventions targeting glial lineages.

Other names: O4Oligodendrocyte MarkerOligo Marker

Mechanism of action

N/A

Biological functions

Cell differentiationMyelinationCell surface antigen

Disease associations

Multiple SclerosisNeurodegenerative disease

Biomarkers

OPC presence/differentiation status

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