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Target intelligence / Profile preview
Oligodendrocyte Progenitor Cell (OPC)
- Target
- OPC
- Molecular classification
- Glial cell, Progenitor cell
01
Overview
Oligodendrocyte progenitor cells (OPCs) are glial cells in the central nervous system that serve as precursors to oligodendrocytes, the myelin-producing cells. OPCs are identified by markers such as PDGFRA, CSPG4/NG2, SOX10, and OLIG2. Their primary function is to generate oligodendrocytes, but they also respond to environmental changes, support the blood-brain barrier, and mediate neuroinflammation. OPCs are a therapeutic target for remyelination strategies in diseases like multiple sclerosis.
- Other names
- NG2-gliaPolydendrocyteOligodendrocyte precursor cellO2A cell
02
Mechanism of action
N/A
03
Biological functions
Precursor for myelinating oligodendrocytesMyelinationSynaptic integrationResponse to CNS environmental changesSupport blood-brain barrier integrityMediating neuroinflammationCell proliferationCell differentiation
04
Disease associations
Demyelination disordersMultiple sclerosis
05
Safety considerations
Potential for uncontrolled proliferationRequirement for tightly regulated differentiation
06
Biomarkers
PDGFRACSPG4/NG2SOX10OLIG2
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