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Oligodendrocyte transcription factor 2 (OLIG2)

Target: OLIG2
Molecular classification: Transcription factor, bHLH family

Overview

OLIG2 is a basic helix-loop-helix (bHLH) transcription factor crucial for central nervous system development. It specifies cell fate among neural progenitors, directing the differentiation of oligodendrocytes and specific types of neurons. OLIG2 plays a role in maintaining progenitor cell pools and is regulated by phosphorylation. Its dysregulation is implicated in neurodevelopmental disorders and brain cancers like glioblastoma multiforme.

Biological functions

Neural DevelopmentMotor neuron differentiationOligodendrocyte differentiationProgenitor cell maintenanceRegulation of gene expressionChromatin remodeling

Disease associations

Neurodevelopmental disordersGlioblastoma multiformeSchizophrenia (ethnicity-dependent)

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