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Oligomannose N-glycans at Asn332 on gp120

Molecular classification: Glycan, Post-translational modification

Overview

Oligomannose N-glycans at Asn332 refer to a specific type of carbohydrate modification found on the HIV-1 envelope glycoprotein gp120. The asparagine residue at position 332 (Asn332) is glycosylated with oligomannose-type structures. These glycans play a critical role in viral infectivity, immune evasion, and are key targets for broadly neutralizing antibodies (bnAbs).

Other names: Asn332 oligomannose glycansgp120 Asn332 glycosylationHIV glycan shield at Asn332

Mechanism of action

Target for broadly neutralizing antibodies (bnAbs), vaccine design

Biological functions

Immune evasionViral infectivityAntibody binding

Disease associations

HIV infection

Safety considerations

Glycan complexity and heterogeneityChallenges in eliciting specific bnAbs

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