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Oligosaccharyltransferase complex non-catalytic subunit (OSTC)
- Target
- OSTC
- Molecular classification
- Other (Subunit of membrane protein complex)
01
Overview
Oligosaccharyltransferase complex non-catalytic subunit (OSTC) is a membrane protein that functions as a subunit of the STT3A-containing oligosaccharyltransferase (OST-A) complex in the endoplasmic reticulum. It acts as an adapter that anchors the OST-A complex to the protein-conducting channel (Sec61 complex), facilitating the co-translational transfer of glycans to asparagine residues in nascent polypeptides—an essential step in protein N-glycosylation. OSTC does not possess catalytic activity itself but is critical for proper assembly and localization of the OST-A complex, and its dysfunction can contribute to specific congenital disorders of glycosylation and potentially influence tumor cell biology through altered glycosylation patterns[1][3][4].
- Other names
- DC2HDCMD45PHSPC307Hydrophobic protein HSF-28DC2 protein
02
Biological functions
Protein N-linked glycosylation via asparagineCo-translational protein modificationAdapter activity in protein complexes
03
Disease associations
Congenital disorder of glycosylation (CDG), type InPotential roles in tumor biology (context-dependent expression and involvement in cell survival/proliferation)
04
Biomarkers
N-glycosylation status of serum glycoproteins (indirect, related to function of the oligosaccharyltransferase complex as a whole)
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