Olive pollen allergen (Ole e 1)

Olive pollen allergens are a family of proteins present in the pollen of *Olea europaea* (olive tree), recognized as major causes of seasonal respiratory allergy, especially in Mediterranean regions where the olive tree is widely cultivated. The allergenic components are diverse, with at least 10 distinct molecules isolated and characterized, among which Ole e 1 is the most clinically relevant as it sensitizes over 70% of olive pollen-allergic patients. These allergens vary by protein family and structure: some are well-characterized enzymes or proteins, such as profilin (Ole e 2), calcium-binding proteins (Ole e 3, Ole e 8), superoxide dismutase (Ole e 5), lipid transfer protein (Ole e 7), and 1,3-beta-glucanase (Ole e 9); others, such as Ole e 1 and Ole e 6, lack clear homology to known proteins and have unknown biological functions in the plant. The proteins provoke IgE-mediated immune responses leading to symptoms of allergic rhinitis, conjunctivitis, and, in susceptible individuals, asthma. Diagnostic and therapeutic strategies target specific allergens, with component-resolved diagnostics identifying IgE reactivity to individual molecules, and allergen immunotherapy aiming to induce tolerance. Variation in allergen content exists between olive cultivars, which can affect diagnosis and treatment efficacy. Note: The query "Olive pollen allergens" is best treated as a class designation, not a single molecular target; for structured data, entries should be per individual allergen (e.g., "Ole e 1", "Ole e 2"), each with unique properties and clinical significance.

Other names

Olive pollen proteinsOlive tree pollen allergen*Olea europaea* pollen allergensOle e familyOle e 1Ole e 2Ole e 6Ole e 7Ole e 9Ole e 10

Immune modulation (allergen-specific immunotherapy modulates T-cell and B-cell responses to reduce allergic Th2 response and induce tolerance)