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Oncogenic long non-coding RNA on chromosome 8 (OLC8)
- Target
- OLC8
- Molecular classification
- Long non-coding RNA (lncRNA), Other (non-protein-coding RNA molecule)
01
Overview
Oncogenic long non-coding RNA on chromosome 8 (OLC8, also known as VPS13B divergent transcript) is a cytoplasmic lncRNA identified on chromosome 8q22 that is significantly upregulated in gastric cancer tissues and cell lines compared to normal tissues. Functional studies show that OLC8 increases cell proliferation and migration, both in vitro and in xenograft models, demonstrating its oncogenic role. Mechanistically, OLC8 binds and stabilizes IL-11 mRNA transcripts, enhancing IL-11 expression and downstream activation of the STAT3 signaling pathway, which in turn promotes gastric cancer progression. Its expression correlates with more advanced tumor stage and metastasis, and the lncRNA is considered a candidate biomarker and potential therapeutic target for gastric cancer.
- Other names
- VPS13B divergent transcriptOLC8AC104986.2ENSG00000253948Oncogenic long non-coding RNA on chromosome 8
02
Mechanism of action
Modulation of gene expression through RNA stabilization. Promotes IL-11 mRNA stability, leading to STAT3 pathway activation, which drives cancer cell growth.
03
Biological functions
Regulation of cell migrationPromotion of cell viabilityEnhancement of cell proliferationStabilization of interleukin-11 (IL-11) mRNAAugmentation of IL-11/STAT3 signaling pathway
04
Disease associations
Cancer (specifically gastric cancer; likely relevance in other cancer contexts due to lncRNA function)
05
Safety considerations
Non-specific targeting may affect normal cell homeostasis, as lncRNAs can regulate broad gene networksPotential for off-target effects due to lncRNA pathway complexityNo specific safety data as no clinical inhibitors or drugs targeting OLC8/VPS13B-DT exist yet
06
Biomarkers
OLC8 expression levels (for prognosis/diagnosis in gastric cancer)Upregulated IL-11 and STAT3 activation downstream of OLC8
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